The Fall of Two Cities tells that in February 2026, an accident occurred during the research on genetic modification of rabies virus in a biological laboratory in Tokyo. The virus mutated and spread, and then an epidemic broke out in New York, plunging many parts of the world into crisis. Junpei Watanabe, a researcher in Tokyo, and Lindsay Miyamoto, a scientist in New York, discovered that the virus was a man-made biological weapon with a "critical point". Only by activating the "Antibody Keys" hidden in laboratories in Tokyo and New York respectively could the disaster be prevented. Breaking through numerous obstacles, the two finally activated the keys simultaneously and released neutralizing mist, thus keeping hope for humanity.
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