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Blanco's first husband was Carlos Trujillo. Together they had three sons, Dixon, Uber, and Osvaldo, all of them poorly educated, and all of whom were killed in Colombia after being deported following prison sentences in the United States.

Her second husband was Alberto Bravo. In 1975, Blanco confronted Bravo, who was also her business partner, in a Bogotá nightclub parking lot about millions of dollars missing from the profits of the cartel they had built together. The Guardian reports: "Blanco, then 32, pulled out a pistol, Bravo responded by producing an Uzi submachine gun and after a blazing gun battle, he and six bodyguards lay dead. Blanco, who suffered only a minor gunshot wound to the stomach, recovered and soon afterward moved to Miami, where her body count – and reputation for ruthlessness – continued to climb."

Blanco had her youngest son, Michael Corleone Blanco, with her third husband, Darío Sepúlveda. Sepúlveda left her in 1983, returned to Colombia, and kidnapped Michael when he and Blanco disagreed over who would take custody. Blanco paid to have Sepúlveda assassinated in Colombia, and her son returned to her in Miami.

According to the Miami New Times, "Michael's father and older siblings were all killed before he reached adulthood. His mom was in prison for most of his childhood and teenage years, and he was raised by his maternal grandmother and legal guardians." In 2012, Michael was put under house arrest after a May arrest on two felony counts of cocaine trafficking and conspiracy to traffic in cocaine. He appeared on a 2018 episode of the Investigation Discovery documentary series, Evil Lives Here, to recount his lonely childhood. In 2019, he was featured in the VH1 docuseries Cartel Crew, which follows the descendants of drug lords. He also runs a clothing brand, "Puro Blanco," that refers to his infamous mother.

Blanco was openly bisexual.

According to her youngest son Michael, Blanco became a born-again Christian.

Griselda Blanco is portrayed by the colombian actress Luces Velásquez in 2012 TV Series Pablo Escobar, The Drug Lord as the character of Graciela Rojas.

The 2017 film, Cocaine Godmother is portrayed by Catherine Zeta-Jones.

In 2018, Griselda was mentioned in the chorus of NBA Young Boy’s song Slime Belief.

In 2012, American rapper Westside Gunn formed a record label called Griselda Records naming it after the infamous drug lord.

Griselda Blanco song by Toronto rappers Pengz and Twotwo

Blanco's story was a source of fascination for writers and artists even before her death. She was profiled in Richard Smitten's 1990 book, The Godmother, and was prominently featured in Billy Corben's 2006 documentary Cocaine Cowboys, as well as its 2008 sequel.

In 2016, it was announced that HBO was developing a film about Blanco's life, with Jennifer Lopez attached to star. The following year, Lifetime also threw its hat into the ring with a biopic titled The Cocaine Godmother, with Catherine Zeta-Jones as the titular character.

Watch Cocaine Godmother: The Griselda Blanco Story on Lifetime Movie Club

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